The COG, with more than 10,000 experts worldwide, has nearly 100 active clinical-translational trials open at any given time. These trials include front-line treatment for many types of childhood cancers, studies aimed at determining the underlying biology of these diseases, and trials involving new and emerging treatments, supportive care, and survivorship.
Topics of discussion have ranged from the mechanisms of metastasis and the structure of the blood brain barrier to strategies for immunotherapy (CAR-T cells and RNA vaccines) to the safety and ethics of research biopsies. Going forward we (PNOC) will continue our discussions of topics of interest, with future sessions planned on drug delivery as well as on late effects and complications of therapy.
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